Detection of Possible Reading Frame Shifts in Genes Using Triplet Frequencies Homogeneity
DOI:
https://doi.org/10.17713/ajs.v40i1&2.205Abstract
A new approach for detecting the reading frame shifts in coding DNA sequences has been developed. To detect the shift the hypothesis of homogeneity of triplet frequencies along the sequence was checked. The statistical significance was estimated by using Monte Carlo method. The method developed has allowed revealing 25% more cases of frame shifts insequences with a length greater than 300, than the approach used earlier.
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