Optimum Mixture Designs for Binomial Two-Parameter Log-Logistic (LL2) Model with Mixture of Two Similar Compounds
Optimal design for log-logistic model (LL2)
Abstract
The paper investigates the class of two-parameter log-logistic dose-response bioassay models in the binomial set-up. The dose is defined by the potency adjusted mixing proportions of two similar compounds. The aim is to investigate the D- and Ds- optimal mixture designs for estimating the full set of parameters or only the potency for a best guess of the parameter values. An indication has been given for finding the optimal design for the estimation of the mixture at which the probability of success attains a given value.
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