Adaptive Allocation Designs for Normal and Binary Treatment Responses
A class of adaptive designs is formulated in two stages for clinical trials to favour the better performing treatment for further allocation in an efficient way. The first stage of the allocation consists in randomizing subjects to each treatment arm with equal probability and performing a test of equality of treatment effects. The resulting p value and the available estimate of a treatment difference measure is used to assign the incoming second stage subjects. Considering binary and normal responses, several exact and asymptotic properties of the proposed allocation are thoroughly examined and compared with the existing allocation designs.
How to Cite
The Austrian Journal of Statistics publish open access articles under the terms of the Creative Commons Attribution (CC BY) License.
The Creative Commons Attribution License (CC-BY) allows users to copy, distribute and transmit an article, adapt the article and make commercial use of the article. The CC BY license permits commercial and non-commercial re-use of an open access article, as long as the author is properly attributed.
Copyright on any research article published by the Austrian Journal of Statistics is retained by the author(s). Authors grant the Austrian Journal of Statistics a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its original authors, citation details and publisher are identified.
Manuscripts should be unpublished and not be under consideration for publication elsewhere. By submitting an article, the author(s) certify that the article is their original work, that they have the right to submit the article for publication, and that they can grant the above license.